Conferenza / Incontro
Telomere transcription and shelterin interactions at human telomeres
Claus Maria Azzalin: Group Leader at Instituto de Medicina Molecular João Lobo Antunes (iMM) (Lisbon, Portugal).
19 febbraio 2024
Orario di inizio
14:30
Polo Ferrari 1 - Via Sommarive 5, Povo (Trento)
Aula A207
Organizzato da:
Dipartimento di Biologia Cellulare, Computazionale e Integrata - CIBIO
Destinatari:
Comunità universitaria
Partecipazione:
Ingresso libero
Referente:
Dipartimento di Biologia Cellulare, Computazionale e Integrata - CIBIO
Contatti:
comunicazione.cibio@unitn.it
Eukaryotic telomeres are transcribed by RNA polymerase II into the long noncoding RNA TERRA. It is widely accepted that telomere transcription and TERRA support crucial cellular functions, including telomerase-mediated and ALT-mediated telomere elongation. However, the molecular details of how TERRA participates in telomere homeostasis maintenance still need to be fully elucidated. I will present an overview of TERRA regulation and functions in human cells. Moreover, I will share unpublished work from my lab revealing a new regulatory circuit based on the physical interactions between TERRA transcripts and telomere-associated proteins including TRF1 and TRF2.
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Locandina Dr. Claus Maria Azzalin (PDF | 335 KB)