Epigenetics Mondays Seminars - Diaferia Giuseppe Riccardo, Ph.D.

Tumor cell heterogeneity in its transcriptional bases in pancreatic cancer

The complexity and the heterogeneity of Pancreatic Ductal Adenocarcinoma (PDAC) have hindered the development of a broadly accepted, clinically actionable classification of PDACs, either on a morphological or a molecular basis. We suggest that such heterogeneity can to a large extent, albeit not exclusively, be traced back to two main classes of PDAC cells that commonly coexist in the same tumor. Using RNA-seq coupled to Laser Microdissection we identified different transcriptional states that allowed us to match different gene expression programs with specific morphological features. This information was used to investigate functional protein networks characterized by important hub genes that in principle may represent druggable targets for the distinct morphological and molecular subtypes.

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