Maria Soledad Sosa
Elucidating the biology of minimal residual disease
Metastasis remains the main cause of human cancer deaths. It has been proposed that disseminated tumor cells (DTCs) are the source for metastasis in several tumor types and that they remain in a reversible
dormant state for prolonged periods of time resisting treatments until, eventually, they will reactivate and form metastasis. Therefore, it is of utmost importance to better understand the mechanisms driving DTC
dormancy and reactivation in order to extend remission and prevent relapse.In this talk, I will present data on dormancy programs, mechanisms of reactivation and potential therapeutic strategies to extend remission phase.
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