Conference / Meeting

NAMPT as a therapeutic target in melanoma: linking NAMPT-dependent metabolic reprogramming and immune regulation

Valentina Audrito - Dipartimento di Scienze e Innovazione Tecnologica, Università del Piemonte Orientale
19 April 2023
Start time 
4:30 pm
Polo Ferrari 2 - Via Sommarive 9, Povo (Trento)
Room B109
Department of Cellular, Computational and Integrative Biology - CIBIO
Target audience: 
University community
Contact person: 
Department of Cellular, Computational and Integrative Biology - CIBIO
Contact details:

Targeted therapy and immune checkpoint inhibitors have improved treatment for BRAF-mutated metastatic melanoma patients, but resistance dramatically impacts survival. Complementary therapies are needed. BRAF inhibitor-resistant cells show increased NAD, supporting metabolic adaptations underlying drug resistance. Nicotinamide phosphoribosyltransferase (NAMPT) is a driver of resistance and progression, and its overexpression correlates with BRAF mutations. Indeed, our preliminary data suggest that NAMPT may have an unknown function in the nucleus and in regulating immune responses, potentially impacting immune checkpoint inhibitors.