Seminar
Single-Cell Chromatin Proteomics to Investigate the Biology of Exceptional Longevity
Simone Sidoli - Scientific Director of the Proteomics Core, Albert Einstein College of Medicine, NY, USA
19 December 2024
Start time
3:30 pm
Polo Ferrari 1 - Via Sommarive 5, Povo (Trento)
Room A106
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Organizer:
Department of Cellular, Computational and Integrative Biology - CIBIO
Target audience:
University community
Attendance:
Free
Contact person:
Department of Cellular, Computational and Integrative Biology - CIBIO
Contact details:
comunicazione.cibio@unitn.it
Our lab studies how histone modifications "protect" chromatin from spurious transcription during aging. We investigate low abundance markers such as histone succinylation and why it accumulates on the chromatin of individuals with projected exceptional longevity, i.e., progeny of centenarians.
To do so, we utilize methods in mass spectrometry to identify proteomes, posttranslational modifications, and quantify their heterogeneity using single cell preparations and analyses.
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Poster Simone Sidoli (PDF | 664 KB)