Venue: Edificio Povo 1, via Sommarive nr. 5, Povo (Tn) - Room A220
Time: 11.30 a.m.
- Achille Pellicioli e Federico Lazzaro - Università di Milano, Dipartimento di Bioscienze
Cells have evolved sophisticated mechanisms, collectively known as DNA damage response (DDR), to protect, preserve and faithfully transmit to the progeny their genome. DDR dysfunctions lead to a pathologic condition called “genome instability”, which is characterized by persistent DNA damage and high rate of chromosome rearrangements and mutations. It is now clear that, genome instability drives to tumorigenesis and other pathologies. We will present our recent works using the budding yeast Saccharomyces cerevisiae as an ideal experimental model to study DDR. Its powerful genetics and versatility, together with the good conservation of DDR factors, are useful to define novel molecular mechanisms and gene networks. Specific topics of the seminar regard the repair of DNA Double Strand Breaks (DSB) and other specific DNA alterations during DNA replication.