Venue: Edificio Povo 2, via Sommarive nr. 9, Povo (Tn) - Room B101
at 2:00 p.m.
- James A. Cowan - Department of Chemistry, The Ohio State University, Columbus, OH 43210
The introduction of metal ions affords many opportunities to design new families of drugs with novel mechanisms of action against specific therapeutic targets. This lecture will review recent progress in our laboratory on the design and study of catalytic metallodrugs against nucleic acid, protein and carbohydrate targets of biomedical interest. Structural, mechanistic, cellular and animal studies provide a glimpse of the therapeutic potential of such molecules and improvements in the areas drug resistance and side effects. Studies of kinetic reactivity and mechanism suggest pathways for improved in vitro and in vivo performance. These advances will be illustrated by selected studies of metallodrugs designed against viral, bacterial, cancer, and cardiovascular disease targets.