Mechanistic insights into the consequences of chromosome segregation errors on cell physiology

Cibio Seminar

June 14th
Versione stampabile

2:30 p.m.
Venue: Aula B102
- Via Sommarive 9, Povo Trento   

  • Stefano Santaguida
    University of Milan - European Institute of Oncology, Milan, Italy 

Aneuploidy, defined as a chromosome number that is not a multiple of the haploid complement, is highly detrimental at both the organismal and cellular levels. 

Virtually all aspects of cell physiology are impacted by changes in the cell’s proteome brought about by an abnormal karyotype. Importantly, aneuploidy is associated with cancer. 

The aneuploid state is an almost universal feature of cancer cells and its high frequency in tumors is a hallmark of the malignant state. 

The goal of our work is to elucidate the impact of aneuploidy on cell physiology by identifying and characterizing at the molecular level the pathways deregulated in aneuploid cells.