Transcriptional and metabolic regulation in naive pluripotent stem cells

25th September 2015
Versione stampabile

Venue: Edificio Povo 2, via Sommarive nr. 9, Povo (Tn) - Room B104
 At 2:00 p.m.

  • Graziano Martello -  Dept. of Molecular Medicine, University of Padova, DTI Telethon Scientist

Pluripotent cells have the unique ability to give rise to all the differentiated cells of the adult body. This cell state is under the control of extrinsic signals stabilising a highly robust network of transcription factors. In the first part of the seminar I will present the approach we used to reconstruct the network controlling the pluripotent cell state. Pluripotent cells are also characterised by a rather unique metabolic profile, where both glycolysis and mitochondrial respiration are performed at high levels. I will share some unpublished results describing a novel mechanism important for tuning the metabolic profile in pluripotent cells and during reprogramming to naive pluripotency.