In vivo experimentation: false myths and reproducibility

Cibio Seminar

17 December 2019
Versione stampabile

Venue: Polo Ferrari 2, via Sommarive 9 (Povo) – Room B104
Time: 14:00 

Speaker

  • Viola Galligioni - Comparative Medicine Unit, Trinity College Dublin

Abstract:

Does it matter which C57BL/6 mouse I choose? Should I be worried if I have Helicobacter spp. or Pseudocapillaria tomentosa in my animal colony? Does enrichment in the animal cage/tank add more variability to my study? Does it matter whether I sample blood from my mouse in the morning or in the afternoon? I don't have enough animals from my colony, why can't I get them from my collaborator's colony? Why should I prefer sub-cutaneous over intra-peritoneal as administration route? Fish don't feel pain...do they?
Whether we work in basic science or in translational research, working in vivo is not trivial and implies various expertise. The scientific community, funding agencies and society are craving for robust reproducible data and Lab Animal Science plays a key role in defining that success.