Alternative splicing and polyadenylation in tumor progression and drug response

Venue: Edificio Povo 2, via Sommarive nr. 9, Povo (Tn) - Room B104
 At 2:00 p.m.

• Martin Dutertre -  S. Vagner's Lab, lnstitut Curie, Orsay, France

The regulation of pre-messenger RNA splicing and cleavage/polyadenylation have been involved in cancer. I will illustrate the contribution of splicing regulation to both qualitative and quantitative regulation of gene expression, and its large-scale regulation in two cancer-related processes: tumor cell metastasis and response to genotoxic anticancer drugs. I will also describe how genome-wide approaches reveal the widespread involvement of a novel mechanism of gene expression regulation involving alternative last exons (or intronic polyadenylation) in both tumor progression and drug response.