Conference / Meeting

Luca Guglielmi, The Francis Crick Institute, London, UK

15 October 2021
Start time 
4:00 pm
Polo Ferrari 1 - Via Sommarive 5, Povo (Trento)
Aula A106
Dipartimento di Biologia Cellulare, Computazionale e Integrata - CIBIO
Target audience: 
University community
Contact person: 
Department of Cellular, Computational and Integrative Biology - CIBIO
Contact details:

From genes to shape: unfolding embryo morphogenesis across scales

During embryogenesis, cells organize across scales to generate the complex three-dimensional (3D) architectures of tissues and organs. To understand how these processes are regulated is crucial to interpret and ameliorate developmental disorders. In this talk I will present my latest work, in which I have uncovered the essential role of the TGF-β family effector SMAD4 in controlling cell fate specification and morphogenesis in the vertebrate embryo. This was achieved using a combination of genome editing, transcriptomics, live imaging and 3D embryo morphometry. Moreover, I will provide examples on how multi-scale approaches can be efficiently translated to unveil complex mechanisms underlaying brain morphogenesis and tackle the cause of severe neurodevelopmental disorders.


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