CIBIO - Ph.D. Colloquia 2019

Seminar series

March-December 2019
Versione stampabile

Time: 4:00 pm
Place: Polo Scientifico Ferrari Povo 2, via Sommarive 9, Povo. 

This is a series of 6 seminars given by top experts in different fields covering almost all the area of the PhD program. Each colloquium is a friendly forum where students can learn how to communicate and critically evaluate science. Additionally, it is an opportunity to discuss ongoing research in an informal atmosphere and obtain valuable feedbacks from the experts.
PhD Colloquia bring together young scientists, senior scientists and students in a colloquial setting, encouraging interactions and exchanges of ideas.

Next Seminar

Tuesday, June 25th

  • Eugenio Fava, DZNE German Center for Neurodegenerative Diseases, Bonn, Germany

Tauopathies are a class of diseases caused by misfolding of the tau protein. In tauopathies tau is phosphorylated abnormally and consequently aggregate and accumulates as intracellular inclusions. Among the class of diseases classified as tauopathies of note are progressive supranuclear palsy (PSP), corticobasal degeneration (CBD), Pick’s disease, and frontotemporal dementias with parkinsonism liked to chromosome 17 (FTDP-17). At the moment there are no disease-modifying therapies for the treatment of tauopathies. Here we show our development of a screening workflow to asses small molecules for their activity on tau aggregation. The cell based assay is based on an inducible N2a cell line which expresses the repeat domain of tau with the pro-aggregant FTDP-mutation ΔK280 (termed Tau4RDΔK280) and develops tau aggregates within a few days. We developed a phenotypic screen to quantify Tau-aggregation on a single cell level. This High-Content Screening (HCS) assay was used to screen a chemogenomic library to assess the effects of compounds on Tau-aggregation. The HCS assay was miniaturized (384well format) and transferred to a robotic screening platform for fully automated and standardized processing. Automated image analysis routines were used to quantify Tau aggregates by Thioflavin S staining and counterstaining of the nuclei by Draq5.

Full programme

Tuesday, March 12th 

  • Adam Cunningham,  Institute of Immunology and Immunotherapy, University of Birmingham, UK

Thursday, May 16th

  • Giorgio Scita, IFOM, the FIRC Institute of Molecular Oncology, Milano, Italy

Thursday, June 13th

  • Alessandro Fatica, Dipartimento di Biologia e Biotecnologie Charles Darwin, Sapienza Università di Roma, Italy

Tuesday, June 25th 

  • Eugenio Fava, DZNE German Center for Neurodegenerative Diseases, Bonn, Germany

Thursday, September 5th

  • Lucilia Saraiva, Department of Biological Sciences, Faculty of Pharmacy - University of Porto, Portugal

Thursday, November 7th

  • Annemieke Aartsma-Rus, Department on Human Genetics LUMC, Leiden University Medical Center, the Netherlands

 

Free entrance. Organized by PhD students enrolled in cycle 32nd.
Info: phd.bioscie [at] unitn.it

 

Sponsored by:

Novagenit S.r.l.                CARLO ERBA Reagents S.r.l          

Eurofins Genomics S.r.l.                Vector Builder GmbH .   

CaRli Biotec               Tema Ricerca

          

Thanks to:

Ristorante Pizzeria DOC          IBRIS focacce e pizze