Modeling the folate-mediated one-carbon metabolism - Extension and compartmentalization
Seminar for the Admission to the Final Exam
2 October 2018
02 October, 2018
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Contatti:
Staff Dipartimento di Matematica
Università degli Studi Trento
38123 Povo (TN)
Tel +39 04 61/281508-1625-1701-3898-1980.
dept.math [at] unitn.it
Luogo: PovoZero, via Sommarive, 14 - Povo - Sala Seminari "-1"
Ore: 11.00
Relatore:
- Misselbeck Karla Magret Eva (PhD Student in Mathematics)
Abstract:
The folate-mediated one-carbon metabolism (FOCM) is an interconnected network of metabolic pathways, whose disruption is associated with neural-tube defects, stroke and certain types of cancer. We use a mathematical model to investigate whether the de novo dTMP synthesis pathway is sensitive to perturbation in FOCM.
Extensions of this model allow us to further study the role of the folate-dependent enzyme MTHFS as well as the impact of the addition of the nuclear compartment on de novo dTMP synthesis.
Referente: Corrado Priami
