Integration of human immune and chromosomal stress responses by the p53 tumor suppressor

Daniel Menendez, Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences (NIEHS), NIH (USA)

23 June 2014
Versione stampabile

June 23 2014
Maso Seminar Room, Via delle Regole n. 101, Mattarello (TN)

2.00 p.m.

The commonly held view of the tumor suppressor p53 as a regulator of cell proliferation, apoptosis and senescence has expanded greatly in recent years to cover many biological processes as well as external and internal stress responses. Since the discovery over 30 years ago there has been an intertwining of p53 activities with immune-related processes, especially as relates to cancer. Here I will discuss examples of interactions between the genome guardian p53 and the immune system at transcriptional level, particularly in response to DNA metabolic and environmental stressors as well as the functional interaction of p53 with the nuclear factor κB (NFκB), a master regulator of the immune responses.