Preclinical characterization of nanodevices for biomedical applications

Luogo: Polo Ferrari 1, via Sommarive nr. 5, Povo - Aula A108
Orario: 11.00

Oratore: 

• Prof. Rosario Maria Sanchez Martin, Universidad de Granada, NanoChemBio Lab, Pfizer-University of Granada-Junta de Andalucía Centre for Genomics and Oncological Research (GENYO)

After several decades of technological advances, drug delivery systems based on multifunctional nanoparticles have emerged as a great promise. However, the translation of the developed nanosystem entails an exhaustive characterization of the nanomaterial to prove that it meets the requirements of the regulatory agencies. NANOCHEMBIO lab is focussed in the technological development and evaluation of nanodevices for cancer diagnosis and therapy. Our research team has designed several strategies to conjugate efficiently therapeutics and diagnostic cargoes to engineered nanoparticles (NPs). Currently our experiments are focused in the preclinical characterisation of this nanodevices following the Assay Cascade of standard operating protocols (SPOs) proposed by the European Nanomedicine Characterisation Lab (EUNCL, www.euncl.eu) for Prescrening, Physicochemical characterisation (PCC), together with the evaluation of their in vitro and in vivo nanotoxicity. Herein our more recent developments in the optimization, batch to batch consistency and scale-up of production together with the evaluation and the characterisation of these multifunctional nanoplatforms for cancer therapy and diagnosis will be presented.