Vascularization strategies in tissue engineering and regenerative medicine

Location: Room B102, Department of Industrial Engineering, via Sommarive 9, Povo-Trento, h: 14.00

• Prof. Sabine Fuchs, Universität Kiel

Abstract

In this lecture we will discuss first the mechanisms involved in guiding neovascularization and vessel maturation ranging from involved molecules and cell types with as strong focus on bone vascularization strategies. Several models to analyse mechanisms of vascularization will be proposed based on mono-cultures and co-cultures of endothelial cells with other cell types. In this context we will discuss some options to enhance tissue vascularization in tissue engineering and regenerative medicine by means of cells, growth factors and morphogens and biomaterial design. Outgrowth endothelial cells and myeloid endothelial progenitor cells will be proposed as proangiogenic cell types which can be harvested by minimal invasive procedures from adult patients and their characteristics and functions will be discussed. This also includes their angiogenic response in co-culture with bone forming cells or material properties but also a potential use to analyse the impact of different factors on tumor vascularization. Finally, we will briefly discuss the role of endothelial cells in an in vitro model of the alveolar-capillary of the lung and their impact on the barrier properties under inflammatory conditions or infections.

The poster is on the download box.