I seminari si terranno online, attrraverso la piattaforma Zoom. Per partecipare, contattare la Segreteria di Dipartimento (dept.math [at] unitn.it)
- Daniel Ortega Ponce (IMDEA Nanociencia e Universidad de Cádiz)
Cancer therapy through magnetic hyperthermia: a complex multiphysics, multidimensional problem
Computer simulations for functional modelling of biological systems are broadly known as in silico tests. In the mid- and long- term, such forecasting procedure will allow for a noticeable reduction of the animals and humans required for in vivo testing, and more importantly, it will provide a precise tool for guiding clinicians in planning clinical studies of modern cancer therapies like magnetic hyperthermia. After the success in past clinical trials and the hopes in the forthcoming ones, such as that on pancreatic cancer coordinated by the NoCanTher project (www.nocanther-project.eu/), computer simulations are becoming a critical tool in treatment planning. The present talk intends to give an overview on some of the mathematical methods involved in the so-called treatment planning process of magnetic hyperthermia, providing specific examples on ways to predict possible secondary effects. Finally, some glimpses will be given on whether or not a unified model for magnetic hyperthermia, while much needed, is feasible.
Modelling parasitic heating of metallic implants during magnetic hyperthermia to adjust clinical exclusion criteria for prospective patients
The so-called treatment planning process for many hyperthermia modalities have benefitted from the developments made in radiotherapy, which reproduce the dose needed to destroy the tumours preserving as much as healthy tissue as possible. The main benefit of the hyperthermia treatment planning is that all cases can be studied beforehand, even those that match with any of the exclusion criteria, evaluating this way their risk and finally rejecting or not their suitability for the treatment. One of the exclusion criteria for prospective participants is that no implant-bearing patients are allowed, which may represent a proportion as high as the 60% of the initial cohort. The reason for this is that partially or totally metallic implants may undergo noticeable heating during the therapy upon being exposed to the magnetic field needed to excite the magnetic nanoparticles, even inducing tissue damage if not properly controlled. In this talk we will address the models predicting how the implant heating process takes place in different indications, and also some graphical representations that may help in properly tackling risk assessment, which will help to recover a sizeable proportion of the initially excluded patients.
Referente: Ana Maria Alonso Rodriguez
I seminari si svolgono all'interno del corso Mathematical Aspects of Bioelectromagnetism and Imaging